For US Residents only
How to Receive KYMRIAH
What is the process for getting KYMRIAH?
You and your treatment team may be considering KYMRIAH® (tisagenlecleucel) but are unsure of the process. Below is a detailed description of each step so you know what to expect with KYMRIAH therapy. To watch patients, LJ and Nick, and their families discuss their experience with each step of the KYMRIAH process, click the video clip next to that step.
KYMRIAH is a therapy for children and young adults up to 25 years of age with B-cell ALL that is refractory or in second or later relapse. Discuss your treatment history and overall health with your doctor to see if you are a candidate for KYMRIAH therapy. Go to What should I ask my treatment team? for help speaking with your doctor.
Find a KYMRIAH Treatment Center
Some people are already receiving treatment for their B-cell ALL at a treatment center that administers KYMRIAH. Others get a referral for KYMRIAH from their primary oncologist. If you haven’t already selected your treatment center, view the list of participating KYMRIAH Treatment Centers, or call KYMRIAH CARES™ at 1-844-4KYMRIAH (1-844-459-6742) for an up-to-date list of treatment centers in the United States so you can find a center near you.
Treatment with KYMRIAH uses your own cells, so the process begins with T cell collection. A small, temporary tube (IV catheter) will be placed into your vein to collect your T cells. This process is called leukapheresis (pronounced loo-kuh-fuh-REE-sis) and takes about 3 to 6 hours.
Preparing for Infusion
Your cells will be sent to a manufacturing facility to be reprogrammed into KYMRIAH CAR-T cells, a process that usually takes about 3 to 4 weeks. To learn more about what happens to your T cells, watch the mechanism of action video. About 2 to 14 days before your CAR-T cells are ready, you will receive a short course of chemotherapy over 4 days that helps prepare your body to receive your reprogrammed KYMRIAH CAR-T cells.
Once your KYMRIAH CAR-T cells are ready, they are put back into your body through a standard IV infusion that usually takes less than 30 minutes. About 30 to 60 minutes before your KYMRIAH infusion, you will receive acetaminophen and an antihistamine.
Once your KYMRIAH CAR-T cells are in your body, they will begin to detect and destroy your cancerous and normal B cells. During the weeks after KYMRIAH infusion, your treatment team will monitor you closely to manage any side effects, some of which may require you to go to the hospital. Remember that some side effects are expected and your treatment team is prepared to help. Go to What side effects may I experience with KYMRIAH? for more information.
Your treatment team may check on your progress about a month after your infusion. After that, they may decide that you can get back to your daily activities.
Balancing It All
The KYMRIAH treatment process is different from that of other cancer therapies. Hear from the parents of a pediatric ALL patient, Nick, to learn how their family managed this process.
You may go see a different doctor who will take some of your cells from your blood and teach them how to look for your cancer cells. Once your cells know how to find your cancer cells, they will be put back into your body to start fighting your cancer.