Understanding KYMRIAH

Is KYMRIAH right for me?

KYMRIAH® (tisagenlecleucel) is approved to treat children and young adults whose B-cell ALL is refractory or in second or later relapse. KYMRIAH is a therapy option for those looking for a different way to try to treat their cancer because previous treatments have not kept their cancer in remission. If you are considering treatment options, ask your doctor about KYMRIAH.

 

Topics to discuss with your doctor:

  • ✓   Your treatment history
  • ✓   Your cancer’s past response to chemotherapy
  • ✓   Any previous bone marrow transplants
  • ✓   Overall health (for example, organ function)
  • ✓   Other conditions you may have (for example, genetic syndromes, hepatitis, viruses)

What is KYMRIAH?

KYMRIAH is not a pill, chemotherapy, or transplant. KYMRIAH is a type of cutting-edge immunotherapy that uses the power of your own immune system to treat your cancer.

 

Watch this brief video to learn how KYMRIAH works.

Learn how KYMRIAH works
9:24

Watch this video to learn how KYMRIAH works. 

A natural defender, the T cell is a part of your immune system. T cells detect and destroy infected ‭or cancerous cells by looking for certain antigens. Antigens are markers on cells that help your ‭immune system identify normal cells from infected or cancerous cells; however, your cancerous ‭B cells look like normal B cells. ‬‬‬

 

‭After KYMRIAH, your T cells will be able to recognize an antigen on your B cells called ‭CD19. By reprogramming your T cells, KYMRIAH enhances their ability to detect and destroy your B cells, including those with cancer in them. Because KYMRIAH uses your own T cells, you may hear it referred to as an “individualized” therapy made just for you.‬ After being treated with KYMRIAH, you may not need any other treatment for your cancer.

 

‭To learn more about the therapy process with KYMRIAH, go to What is the process for getting KYMRIAH?.

 

To learn more about KYMRIAH, download Your guide to KYMRIAH therapy

KYMRIAH for Kids
How does KYMRIAH work?

KYMRIAH is a special kind of medicine that trains some of your cells to be cancer-fighting cells. Your trained cells will help fight your cancer.

How do my T cells become KYMRIAH CAR-T cells?

KYMRIAH is a unique therapy that starts and ends with you. Your cells make KYMRIAH possible, so the process begins with your T cell collection and ends with infusing them back into you. For a more detailed description of KYMRIAH therapy, go to What is the KYMRIAH therapy process?.

T cell collection
Collection
First, your doctor takes some of your blood to collect your T cells. Then, they are frozen and sent to be reprogrammed into KYMRIAH CAR-T cells.
T cell reprogramming
Reprogramming
Next, your T cells are reprogrammed into KYMRIAH CAR-T cells. The CAR in CAR-T stands for chimeric antigen receptor. This CD19-detecting receptor gives your T cells a new way to target your B cells.
KYMRIAH infusion
Infusion
Once your KYMRIAH CAR-T cells are returned to your body, they are ready to begin detecting and destroying your cancer.

What makes KYMRIAH different from other therapies?

KYMRIAH is different from other cancer therapies because it is a treatment that comes from within you.

 

  • KYMRIAH is given as a single infusion unlike other treatments delivered more than once
  • KYMRIAH targets only your B cells rather than all of your body’s cells
  • KYMRIAH uses a short course (4 days) of chemotherapy to prepare your body for infusion
  • Even if you aren’t in remission, you can start KYMRIAH therapy
  • Because KYMRIAH uses your own cells, you do not need a donor

 

KYMRIAH for Kids
How is KYMRIAH different from other medicines?

KYMRIAH is not like other medicines you may have tried. KYMRIAH uses your own body’s strength to fight your cancer.